Thank you for your question. We can ensure that you eating durian and drinking Coca-Cola at the same time do no harm to your health. Related Items FAQ More on Journey Coca-Cola FAQs: Drinks Do caffeinated drinks like Coca‑Cola count towards my recommended daily water intake? Is it true that you can die from eating Mentos and drinking Coke at the same time? Does Coca-Cola taste different in different countries? Is Coca‑Cola bad for my teeth?